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The effect of methamphetamine on the neuroimmune system
Petrášová, Blanka ; Hejnová, Lucie (advisor) ; Lapka, Marek (referee)
Metamphetamine is worldwide problem and in the Czech republic is 2-3 % of people older than 15 years exposed to it. There are 34,7 thousand long-term users in Czech republic and 19 methamphetamine-related deaths in 2022. The impact on the neuroimmune system has only started to be studied in recent years. Understanding its effect on the neuroimmune system may outline new treatment options, as there is no cure for methamphetamine addiction to date. This paper summarizes its effects on the different components of the neuroimmune system and outlines some substances that could be used in treatment. Key words: methamphetamine, neuroimmune system, inflammation, microglia, astrocytes
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Involvement of the neuroimmune system in Alzheimer's disease
Chaloupková, Barbora ; Hejnová, Lucie (advisor) ; Vašek, Daniel (referee)
Alzheimer's disease afflicts more and more people with increasing life expectancy. The causes of this disease are still not fully understood and explained. An effective treatment is still lacking. One of the reasons is a lack of effective biomarkers of the disease in its early stages before the onset of cognitive deficits. Current research focuses on the neuroimmune system. Emerging evidence shows that changes in its function play a significant role in Alzheimer's disease. This bachelor's thesis describes the interaction of components of the neuroimmune system in the preclinical stages and progression of Alzheimer's disease, their use as biomarkers in the diagnosis of preclinical and clinical stages of AD, and subsequently their potential use in the therapeutic treatment of AD. Key words: Alzheimer's disease, neuroimmune system, neuroinflammation, therapeutic treatment, biomarkers
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Immune mechanisms in inflammatory pain
Vašek, Daniel ; Krulová, Magdaléna (advisor) ; Melkes, Barbora (referee)
Pain is one of the five symptoms of inflammation. Activation and regulation of pain are affected both by the nervous system and the immune system. The production of inflammatory mediators decreases the threshold for activation of the ion channels of peripheral nociceptors, which then result in painful sensations caused by otherwise innocuous stimuli. Such mediators are cytokines, bradykinin, prostaglandins or various neurotrophic factors. This work aims to explain the function of immune cells in the production of these inflammatory and painful modulators. The study of activation and sensitization of nociceptors in inflammation is important for the understanding of the whole mechanism of inflammatory pain as well as for a comprehensive understanding of the neuroimmune system. Understanding inflammatory pain can lead to the development of specific drugs against it. Key words: inflammation, pain, inflammatory pain, immune system, neuroimmune system
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